BDBM367632 N-((1R,2R)-1-(4-cyclopropoxy-3- fluorophenyl)-1-hydroxy-3-(pyrrolidin- 1-yl)propan-2-yl)-7-(4-fluorophenyl)- N-methyl-1H-benzo[d][1,2]oxazine-4- carboxamide::US10227312, Example 17::US10759769, Example 17

SMILES CN([C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(F)c1)C(=O)C1=NOCc2cc(ccc12)-c1ccc(F)cc1

InChI Key InChIKey=WDTDONAGUPXCAN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367632   

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367632(US10227312, Example 17 | N-((1R,2R)-1-(4-cycloprop...)
Affinity DataIC50: 5.5nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetCeramide glucosyltransferase(Human)
Biomarin Pharmaceutical

US Patent
LigandPNGBDBM367632(US10227312, Example 17 | N-((1R,2R)-1-(4-cycloprop...)
Affinity DataIC50: 5.5nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent