BDBM367645 N-((1R,2R)-3-(azetidin-1-yl)-1-(3- chloro-4-cyclopropoxyphenyl)-1- hydroxypropan-2-yl)-8-fluoro-1H- naphtho[2,1-d][1,2]oxazine-4- carboxamide::US10227312, Example 30::US10759769, Example 30

SMILES O[C@@H]([C@@H](CN1CCC1)NC(=O)C1=NOCc2c1ccc1cc(F)ccc21)c1ccc(OC2CC2)c(Cl)c1

InChI Key InChIKey=QMONKTOQXXUXGZ-SHQCIBLASA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367645   

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367645(N-((1R,2R)-3-(azetidin-1-yl)-1-(3- chloro-4-cyclop...)
Affinity DataIC50:  5.5nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367645(N-((1R,2R)-3-(azetidin-1-yl)-1-(3- chloro-4-cyclop...)
Affinity DataIC50:  5.5nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent