BDBM367659 N-((1R,2R)-1-(3-chloro-4- cyclopropoxyphenyl)-1-hydroxy-3- (pyrrolidin-1-yl)propan-2-yl)-7- (cyclohexylmethoxy)-1H- benzo[d][1,2]oxazine-4-carboxamide::US10227312, Example 45::US10759769, Example 45

SMILES O[C@@H]([C@@H](CN1CCCC1)NC(=O)C1=NOCc2cc(OCC3CCCCC3)ccc12)c1ccc(OC2CC2)c(Cl)c1

InChI Key InChIKey=QKRBHZOKGTZZNH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367659   

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367659(US10227312, Example 45 | N-((1R,2R)-1-(3-chloro-4-...)
Affinity DataIC50: 5.5nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367659(US10227312, Example 45 | N-((1R,2R)-1-(3-chloro-4-...)
Affinity DataIC50: 5.5nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent