BDBM367660 N-((1R,2R)-1-(4-cyclopropoxy-3- fluorophenyl)-1-hydroxy-3-(pyrrolidin- 1-yl)propan-2-yl)-1-methyl-1,9- dihydro[1,2]oxazino[4,5-g]indazole-6- carboxamide::US10227312, Example 46::US10759769, Example 46

SMILES Cn1ncc2ccc3C(=NOCc3c12)C(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc(OC2CC2)c(F)c1

InChI Key InChIKey=WPGIJFUUMSMKGM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 367660   

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367660(US10227312, Example 46 | N-((1R,2R)-1-(4-cycloprop...)
Affinity DataIC50: 5.5nMAssay Description:Protein concentration was determined using BCA assay kit. Sixty micrograms of MDCK cell lysate was incubated with various concentrations of a compoun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

TargetCeramide glucosyltransferase(Human)
TBA

US Patent
LigandPNGBDBM367660(US10227312, Example 46 | N-((1R,2R)-1-(4-cycloprop...)
Affinity DataIC50: 5.5nMAssay Description:This assay was modified based on the study by Larsen et al. (J. Lipid Res. 2011, 53, 282). Madin-Darby canine kidney (MDCK) cell lysate was prepared ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent