BDBM367752 US10227329, Compound 164

SMILES C[C@H](NC(=O)C1CCN(CC1)c1cc(C)cc(Nc2cc(C)[nH]n2)n1)c1ccc(nc1)-n1cc(F)cn1

InChI Key InChIKey=BBBIXJCRZSLELY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 367752   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Blueprint Medicines

US Patent
LigandPNGBDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of mutant RET (ProQinase 1096-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 10nMAssay Description:In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 73nMAssay Description:The experimental steps are as follows:(1) The test compound (the compound of the present disclosure, and compound 164 in WO2018017983A1 as a control)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Zhejiang Hisun Pharmaceutical

US Patent
LigandPNGBDBM367752(US10227329, Compound 164 | US12234222, Compound 16...)
Affinity DataIC50: 2.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2025
Entry Details
US Patent