BDBM368206 (2R,5S)-5-[1-(cyclopropylmethyl)- 1H-pyrazol-4-yl]-2-methyl-1-{[2- (2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidine::US10227336, Example 3

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1cnn(CC2CC2)c1

InChI Key InChIKey=JXEMOSBQUQVRNZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368206   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368206((2R,5S)-5-[1-(cyclopropylmethyl)- 1H-pyrazol-4-yl]...)
Affinity DataIC50: 124nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368206((2R,5S)-5-[1-(cyclopropylmethyl)- 1H-pyrazol-4-yl]...)
Affinity DataIC50: 7.71E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent