BDBM368210 US10227336, Example 7::methyl 2-methyl-2-{4-[(3S,6R)-6- methyl-1-{[2-(2H-1,2,3-triazol-2- yl)phenyl]carbonyl}piperidin-3-yl]- 1H-pyrazol-1-yl}propanoate

SMILES COC(=O)C(C)(C)n1cc(cn1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-n1nccn1

InChI Key InChIKey=JKHUPHRIVNHDEC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368210   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368210(methyl 2-methyl-2-{4-[(3S,6R)-6- methyl-1-{[2-(2H-...)
Affinity DataIC50: 46nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368210(methyl 2-methyl-2-{4-[(3S,6R)-6- methyl-1-{[2-(2H-...)
Affinity DataIC50: 3.05E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent