BDBM368211 (2R,5S)-5-(1-cyclobutyl-1H-pyrazol- 4-yl)-2-methyl-1-{[2-(2H-1,2,3- triazol-2- yl)phenyl]carbonyl}piperidine::US10227336, Example 8

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)c1cnn(c1)C1CCC1

InChI Key InChIKey=RIYNNEBEVKBSIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368211   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368211((2R,5S)-5-(1-cyclobutyl-1H-pyrazol- 4-yl)-2-methyl...)
Affinity DataIC50: 49nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368211((2R,5S)-5-(1-cyclobutyl-1H-pyrazol- 4-yl)-2-methyl...)
Affinity DataIC50: 3.44E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent