BDBM368216 2[3-({(2R,5S)-2-methy1-5-[1-(1- methylethyl)-1H-pyrazol-4- yl]piperidin-1- yl}carbonyl)thiophen-2- yl]pyrimidine::US10227336, Example 13

SMILES CC(C)n1cc(cn1)[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccsc1-c1ncccn1

InChI Key InChIKey=PZFTYBRKQKIGAH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368216   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368216(2[3-({(2R,5S)-2-methy1-5-[1-(1- methylethyl)-1H-py...)
Affinity DataIC50: 155nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM368216(2[3-({(2R,5S)-2-methy1-5-[1-(1- methylethyl)-1H-py...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent