BDBM368543 1-(piperidin-1-yl)-N-(1H- pyrazolo[4,3-b]pyridin-3- yl)isoquinolin-6-amine::US10227343, Example 75

SMILES c1cnc2c(Nc3ccc4c(N5CCCCC5)nccc4c3)n[nH]c2c1

InChI Key InChIKey=GGYXNEFKIIDDMJ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368543   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandChemical structure of BindingDB Monomer ID 368543BDBM368543(1-(piperidin-1-yl)-N-(1H- pyrazolo[4,3-b]pyridin-3...)
Affinity DataEC50:  215nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandChemical structure of BindingDB Monomer ID 368543BDBM368543(1-(piperidin-1-yl)-N-(1H- pyrazolo[4,3-b]pyridin-3...)
Affinity DataEC50:  215nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed