BDBM368553 N-(naphthalen-2-yl)-1H- pyrazolo[4,3-b]pyridin-3- amine::US10227343, Example 88

SMILES c1ccc2cc(Nc3n[nH]c4cccnc34)ccc2c1

InChI Key InChIKey=FAUFNAAZZSERRI-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368553   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandChemical structure of BindingDB Monomer ID 368553BDBM368553(N-(naphthalen-2-yl)-1H- pyrazolo[4,3-b]pyridin-3- ...)
Affinity DataEC50:  403nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandChemical structure of BindingDB Monomer ID 368553BDBM368553(N-(naphthalen-2-yl)-1H- pyrazolo[4,3-b]pyridin-3- ...)
Affinity DataEC50:  403nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed