BDBM369388 US12528814, Example 171

SMILES CNc1cc(-c2ccc3cc(C#N)cnn23)ncc1-c1nnc([C@H]2CC[C@H](N(C)C[C@@H]3CCN(c4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=O)C3)CC2)s1

InChI Key InChIKey=CYCJYOGKSCFPRB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 369388   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nurix Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 369388BDBM369388(US12528814, Example 171)
Affinity DataIC50: 0.400nMAssay Description:The binding capacities of certain bifunctional compounds of Formula (I) were determined using the CisBio HTRF KinEASE STK S1 Kit (#62ST1PEB, contains...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2026
Entry Details
US Patent