BDBM370465 1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindol-5-yl)ethanol;::US10233190, Example 1376

SMILES OC(CC1c2ccc(F)cc2-c2cncn12)C1CCCCC1

InChI Key InChIKey=GZLGDNBVPZDDHN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 370465   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370465(1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindo...)
Affinity DataIC50:  550nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370465(1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindo...)
Affinity DataEC50:  2.70E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370465(1-cyclohexyl-2-(8-fluoro-5H-imidazo[5,1- a]isoindo...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed