BDBM370862 N-ethyl-N-{2-[5-(1-hydroxy-1- methylethyl)pyridin-2-yl]ethyl}-2- (2,2,2-trifluoroethoxy)pyridine-3- carboxamide::US10239838, Example 56

SMILES CCN(CCc1ccc(cn1)C(C)(C)O)C(=O)c1cccnc1OCC(F)(F)F

InChI Key InChIKey=DDEVUHLQGABAIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 370862   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM370862(US10239838, Example 56 | N-ethyl-N-{2-[5-(1-hydrox...)
Affinity DataIC50: 430nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM370862(US10239838, Example 56 | N-ethyl-N-{2-[5-(1-hydrox...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent