BDBM372083 3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-yl]-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 106::US10435407, Example 106

SMILES FC(F)(F)CN1CC[C@@H](N2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3cnc4[nH]ncc4c3)C2=O)C1=O

InChI Key InChIKey=QGAZPZGGCFPPIQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372083   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372083BDBM372083(3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-...)
Affinity DataIC50: 80.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372083BDBM372083(3-[(+)-2-Oxo-1-(2,2,2-trifluoroethyl)pyrrolidin-3-...)
Affinity DataIC50: 80.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent