BDBM373352 US20260022125, Example 6.26::{4-[(4-fluoro-2-methyl-1H- indol-5-yl)oxy]-5- methylpyrrolo[1,2-b]pyridazin- 6-yl}[(3R)-3- methoxypyrrolidin-1- yl]methanone

SMILES CO[C@@H]1CCN(C(=O)c2cn3nccc(Oc4ccc5[nH]c(C)cc5c4F)c3c2C)C1

InChI Key InChIKey=OUBBUIANRNHDIX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373352   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373352BDBM373352({4-[(4-fluoro-2-methyl-1H- indol-5-yl)oxy]-5- meth...)
Affinity DataEC50:  1.60nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent