BDBM373367 N-ethyl-5-({6-[(3S)-3- hydroxy-3-methylpyrrolidine- 1-carbonyl]-5- methylpyrrolo[1,2-b]pyridazin- 4-yl}oxy)-2-methyl-1H-indole- 1-carboxamide::US20260022125, Example 6.38

SMILES CCNC(=O)n1c(C)cc2cc(Oc3ccnn4cc(C(=O)N5CC[C@](C)(O)C5)c(C)c34)ccc21

InChI Key InChIKey=JRFASOGSNHOLCF-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373367   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373367BDBM373367(N-ethyl-5-({6-[(3S)-3- hydroxy-3-methylpyrrolidine...)
Affinity DataEC50:  1.10nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent