BDBM373398 N,2-dimethyl-6-({5-methyl-6- [(2S)-2- (trifluoromethyl)azetidine-1- carbonyl]pyrrolo[1,2- b]pyridazin-4-yl}oxy)-1- benzofuran-3-carboxamide::US20260022125, Example 7.18

SMILES CNC(=O)c1c(C)oc2cc(Oc3ccnn4cc(C(=O)N5CC[C@H]5C(F)(F)F)c(C)c34)ccc12

InChI Key InChIKey=ZGDMJHZPORYKFJ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373398   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373398BDBM373398(N,2-dimethyl-6-({5-methyl-6- [(2S)-2- (trifluorome...)
Affinity DataEC50:  1.10nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent