BDBM373460 N-(cyclopropylmethyl)-6-({6- [(2R,3R)-3-hydroxy-2- methylazetidine-1-carbonyl]-5- methylpyrrolo[1,2-b]pyridazin- 4-yl}oxy)-2-methyl-1- benzofuran-3-carboxamide::US20260022125, Example 7.66

SMILES Cc1oc2cc(Oc3ccnn4cc(C(=O)N5C[C@@H](O)[C@H]5C)c(C)c34)ccc2c1C(=O)NCC1CC1

InChI Key InChIKey=WZUZFMBUYKKERR-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373460   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 373460BDBM373460(N-(cyclopropylmethyl)-6-({6- [(2R,3R)-3-hydroxy-2-...)
Affinity DataEC50:  1.5nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent