BDBM373700 US10246444, Example 36

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC(=O)C1CSSC1

InChI Key InChIKey=UTVGMDHMDAFOBZ-UHFFFAOYSA-N

Data  6 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 373700   

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 18nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-751,753-758,760-1210](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,747-749,751-1210](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd:  110nMAssay Description:Binding affinity to human partial length EGFR E746-A750 deletion mutant expressed in bacterial expression system by KinomeScan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 210nMAssay Description:Inhibition of probe binding to wild type EGFR (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataIC50: 730nMAssay Description:Inhibition of probe binding to HER2 (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373700(US10246444, Example 36)
Affinity DataKd: >1.00E+4nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent