BDBM373710 US10246444, Example 94

SMILES CC(=O)SCC(CSC(C)=O)C(=O)Nc1cc2c(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c(cnc2cc1OC[C@H](O)CO)C#N

InChI Key InChIKey=LHJVOUDPKROHFZ-UHFFFAOYSA-N

Data  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 373710   

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under full equilibrating...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under partial equilibrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Sabila Biosciences

US Patent
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  50nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  58nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under equilibrate/3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373710(US10246444, Example 94)
Affinity DataKd:  60nMAssay Description:Binding affinity to human partial length EGFR L858R mutant (R669 to V1011 residues) expressed in bacterial expression system under predilution/full e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed