BDBM373730 US10246444, Example 61

SMILES Fc1cccc(COc2ccc(Nc3c(cnc4ccc(NC(=O)C5CSSC5)cc34)C#N)cc2Cl)c1

InChI Key InChIKey=XSGCQHSBQMZVQA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 373730   

TargetEpidermal growth factor receptor(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373730(US10246444, Example 61)
Affinity DataIC50: 199nMAssay Description:Inhibition of probe binding to EGFR L858R mutant (unknown origin) using rabbit reticulate lysate system after 1 hr by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373730(US10246444, Example 61)
Affinity DataIC50: 284nMAssay Description:Inhibition of HER4 (unknown origin) in presence of radiolabelled gammaATP by radioisotope filter binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Sabila Biosciences

Curated by ChEMBL
LigandPNGBDBM373730(US10246444, Example 61)
Affinity DataIC50: 550nMAssay Description:KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent