BDBM374713 11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-ethenopyrazolo[4,3-f][1,4,8,10] benzodioxatriazacyclotridecin-4(5H)-one::US10246466, Example 20::US10618912, Example 20

SMILES CN1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23

InChI Key InChIKey=NRFMLFPXDKIQBF-UHFFFAOYSA-N

Data  17 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 374713   

TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase PLK4(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  2.90nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd: >1.00E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  4.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK3(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  21nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHigh affinity nerve growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.0310nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetNT-3 growth factor receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.300nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK1(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd: >1.00E+3nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  4.80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK3(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetALK tyrosine kinase receptor(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  80nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  21nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetBDNF/NT-3 growth factors receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374713(11-fluoro-14-methyl-6,7,13,14-tetrahydro- 1,15-eth...)
Affinity DataKd:  0.180nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent