BDBM374726 (7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)- one::US10246466, Example 92::US10618912, Example 92

SMILES C[C@@H]1CNC(=O)c2cnn3ccc(N[C@H](C)c4cc(F)ccc4O1)nc23

InChI Key InChIKey=FIKPXCOQUIZNHB-GHMZBOCLSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374726   

TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374726((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataKd:  0.120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374726((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataKd:  8.20nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Tp Therapeutics

US Patent
LigandPNGBDBM374726((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataKd:  0.120nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
In DepthDetails US Patent


TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374726((7R,13R)-11-fluoro-7,13-dimethyl-6,7,13,14- tetrah...)
Affinity DataKd:  8.20nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
In DepthDetails US Patent