BDBM374798 N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide ::US10251893, Cpd 3

SMILES COc1ccc2nc(NC(=O)Cc3ccc(cc3)-c3ccncc3)sc2c1

InChI Key InChIKey=IVXHZSZBXWENCY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 374798   

TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM374798(N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4...)
Affinity DataIC50:  1.60nMAssay Description:Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374798(N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374798(N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374798(N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4...)
Affinity DataIC50:  800nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Mus musculus)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM374798(N-(6-methoxybenzo [d]thiazol-2-yl)-2-(4-(pyridin-4...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with TM3 cells transfected with Wnt-luciferase gene after 24 hrs by lumine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed