BDBM375381 US10358436, Example A99::US9907800, Example A98::US9907800, Example A99

SMILES CCN1CCN(c2ccc(-c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccc(OC)cc56)ccc34)cc2)CC1

InChI Key InChIKey=DTPIGHJZEZDEAO-UHFFFAOYSA-N

Data  13 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 375381   

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.60nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/27/2021
Entry Details Article
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TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 8.5nMAssay Description:Inhibition of AURKB (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/27/2021
Entry Details Article
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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 62nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/27/2021
Entry Details Article
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TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/27/2020
Entry Details
Copy BDB DOIUS Patent

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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/27/2020
Entry Details
Copy BDB DOIUS Patent

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TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
Copy BDB DOIUS Patent

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TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/27/2020
Entry Details
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TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetAurora kinase A(Human)
University Health Network

US Patent

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetAurora kinase A(Human)
University Health Network

US Patent

LigandBDBM375381(US9907800, Example A98 | US9907800, Example A99 | ...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AURKA (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/27/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL