BDBM375443 US10358436, Example A154::US9907800, Example A154

SMILES O=C1Nc2ccccc2[C@]11CC1c1ccc2c(n[nH]c2c1)-c1ccc(CN2CCOCC2)cc1

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 375443   

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50: <100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50:  550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50:  550nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50:  550nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50: <500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50:  550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM375443(US10358436, Example A154 | US9907800, Example A154)
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent