BDBM375573 5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluorotetrahydro-2H-pyran-4-yl)oxy)benzonitrile::US10253019, Example 298

SMILES Cc1cc(Nc2ncnc(n2)-c2ccc(O[C@H]3CCOC[C@H]3F)c(c2)C#N)ccc1N1CCNCC1

InChI Key InChIKey=NLFDTXDESRPTDL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375573   

LigandPNGBDBM375573(5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,...)
Affinity DataIC50: 1nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM375573(5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,...)
Affinity DataIC50: 4nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Gilead Sciences

US Patent
LigandPNGBDBM375573(5-(4-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1,...)
Affinity DataIC50: 373nMAssay Description:Enzymatic activity of hJAK2 was measured using a LANCE homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that monitors...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent