BDBM376367 N-(3- (ethylcarbamoyl) benzyl)-6H- isochromeno [3,4-c] pyridine-8-carboxamide::US9914740, VII-5

SMILES CCNC(=O)c1cccc(CNC(=O)c2ccc-3c(COc4cnccc-34)c2)c1

InChI Key InChIKey=YKJXZODWOQJHCQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376367   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376367(US9914740, VII-5 | N-(3- (ethylcarbamoyl) benzyl)-...)
Affinity DataIC50: 0.800nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376367(US9914740, VII-5 | N-(3- (ethylcarbamoyl) benzyl)-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376367(US9914740, VII-5 | N-(3- (ethylcarbamoyl) benzyl)-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed