BDBM376385 N-((R)-1-(4-fluorophenyl) ethyl)-6-methyl-6H- isochromeno[3,4-c]pyridine- 8-carboxamide::US9914740, VIII-11

SMILES C[C@@H](NC(=O)c1ccc-2c(c1)C(C)Oc1cnccc-21)c1ccc(F)cc1

InChI Key InChIKey=WPRSXKAJNSRNRR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376385   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376385(US9914740, VIII-11 | N-((R)-1-(4-fluorophenyl) eth...)
Affinity DataIC50: 2.54nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent