BDBM376397 6-cyclopropyl-N-((R)-1-(3- methoxyphenyl)ethyl)-6H- isochromeno[3,4-c]pyridine- 8-carboxamide::US9914740, VIII-23

SMILES COc1cccc(c1)[C@@H](C)NC(=O)c1ccc-2c(c1)C(Oc1cnccc-21)C1CC1

InChI Key InChIKey=IMUQMJFWSHDHRX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 376397   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376397(US9914740, VIII-23 | 6-cyclopropyl-N-((R)-1-(3- me...)
Affinity DataIC50: 0.720nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM376397(US9914740, VIII-23 | 6-cyclopropyl-N-((R)-1-(3- me...)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM376397(US9914740, VIII-23 | 6-cyclopropyl-N-((R)-1-(3- me...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed