BDBM376644 1-Methyl-5-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4-yl)-4- (tetrahydro-2H-pyran-3-yloxy)-1,3- dihydro-2H-benzimidazol-2-one::US9918990, Example 91

SMILES Cn1c2ccc(c(OC3CCCOC3)c2[nH]c1=O)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key InChIKey=KNGIUNOBEQAVKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376644   

TargetBromodomain-containing protein 2(Human)
Incyte

US Patent
LigandPNGBDBM376644(1-Methyl-5-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Incyte

US Patent
LigandPNGBDBM376644(1-Methyl-5-(6-methyl-7-oxo-6,7-dihydro- 1H-pyrrolo...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent