BDBM376851 (R)-(2-(2,2- difluoroethyl)phenyl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 12::US9920038, 20

SMILES Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2CC(F)F)nc1C(C)(C)O

InChI Key InChIKey=BQAGHVYUCGUOIX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 376851   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376851(US9920038, 20 | (R)-(2-(2,2- difluoroethyl)phenyl)...)
Affinity DataIC50: 98nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376851(US9920038, 20 | (R)-(2-(2,2- difluoroethyl)phenyl)...)
Affinity DataIC50: 112nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376851(US9920038, 20 | (R)-(2-(2,2- difluoroethyl)phenyl)...)
Affinity DataIC50: 690nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376851(US9920038, 20 | (R)-(2-(2,2- difluoroethyl)phenyl)...)
Affinity DataIC50: 2.18E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent