BDBM376860 (R)-(3-(2H-1,2,3-triazol-2- yl)pyridin-2-yl)(2-((4-(2- hydroxypropan-2-yl)-5- methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 21

SMILES Cc1oc(C[C@H]2CCCCN2C(=O)c2ncccc2-n2nccn2)nc1C(C)(C)O

InChI Key InChIKey=HMMWEDJZZZOSCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376860   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376860(US9920038, 21 | (R)-(3-(2H-1,2,3-triazol-2- yl)pyr...)
Affinity DataIC50: 225nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376860(US9920038, 21 | (R)-(3-(2H-1,2,3-triazol-2- yl)pyr...)
Affinity DataIC50: 1.85E+3nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent