BDBM376866 (2-(2,2- difluorocyclopropyl)phenyl)((R)- 2-((4-(2-hydroxypropan-2-yl)- 5-methyloxazol-2- yl)methyl)piperidin-1- yl)methanone::US9920038, 27

SMILES Cc1oc(C[C@H]2CCCCN2C(=O)c2ccccc2C2CC2(F)F)nc1C(C)(C)O

InChI Key InChIKey=ZIYMJIJGCMRLHP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376866   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376866(US9920038, 27 | (2-(2,2- difluorocyclopropyl)pheny...)
Affinity DataIC50: 38nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM376866(US9920038, 27 | (2-(2,2- difluorocyclopropyl)pheny...)
Affinity DataIC50: 473nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent