BDBM376897 N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyrimidin-2-yl]-4-hydroxypiperidin-4-yl}methyl)-1H-pyrazole-4-carboxamide (E27)::US9920053, Example 27

SMILES OC1(CNC(=O)c2cn[nH]c2)CCN(CC1)c1nc(Oc2cccc(F)c2)cc(n1)C(F)(F)F

InChI Key InChIKey=AUYRMMWRSKKNRI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 376897   

TargetSodium-dependent dopamine transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376897(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  19.1nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376897(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  5.01E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSodium-dependent serotonin transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376897(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  3.47E+4nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSodium-dependent noradrenaline transporter(Human)
Chronos Therapeutics

US Patent
LigandPNGBDBM376897(N-({1-[4-(3-fluorophenoxy)-6-(trifluoromethyl)pyri...)
Affinity DataIC50:  2.24E+3nMAssay Description:The affinity of the compounds of the invention to the human DAT or NET or SERT transporters is assessed by using the [3H]WIN-35,428 or [3H]nisoxetine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent