BDBM377114 9-[1-(4-amino-3-methyl- 1H-pyrazolo[3,4- d]pyrimidin-1-yl)ethyl]-7- chloro-2-methyl-4-(1- propionylazetidin-3-yl)- 2,3,4,5-tetrahydro-1,4- benzoxazepine-6- carbonitrile::US10259818, Example 96::US9944646, Example 96

SMILES CCC(=O)N1CC(C1)N1C[C@H](C)Oc2c(cc(Cl)c(C#N)c2C1)C(C)n1nc(C)c2c(N)ncnc12

InChI Key InChIKey=BADSRNFTUIHDCK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377114   

LigandChemical structure of BindingDB Monomer ID 377114BDBM377114(US9944646, Example 96 | US10259818, Example 96 | 9...)
Affinity DataIC50: 100nMAssay Description:[γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 377114BDBM377114(US9944646, Example 96 | US10259818, Example 96 | 9...)
Affinity DataIC50: 100nMAssay Description:The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details
US Patent