BDBM377176 US10259811, Example 175

SMILES N#Cc1cc(-c2ccnc3[nH]c(C4=CCC5(CC4)OCCO5)cc23)ccc1OC1CCN(C(=O)CO)CC1

InChI Key InChIKey=SXFYXPVAKZPFNY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377176   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 377176BDBM377176(US10259811, Example 175)
Affinity DataIC50: 1.46nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 377176BDBM377176(US10259811, Example 175)
Affinity DataIC50: 5.84nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent