BDBM377614 4-{[(6-fluoro-7-methoxy-2-oxo-::US10266495, Compound I-26

SMILES COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2cc1F

InChI Key InChIKey=GPCTVBQLFMBFGO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377614   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 377614BDBM377614(US10266495, Compound I-26 | 4-{[(6-fluoro-7-methox...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Sunshine Lake Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 377614BDBM377614(US10266495, Compound I-26 | 4-{[(6-fluoro-7-methox...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent