BDBM377622 4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10266495, Compound I-34

SMILES COc1cc(C#N)ccc1NCc1cc2cc(Cl)ccc2[nH]c1=O

InChI Key InChIKey=HCZKGKHYRPTOOB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377622   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Forma Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 377622BDBM377622(US10266495, Compound I-34 | 4-{[(6-chloro-2-oxo-1,...)
Affinity DataIC50: 147nMAssay Description:Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 377622BDBM377622(US10266495, Compound I-34 | 4-{[(6-chloro-2-oxo-1,...)
Affinity DataIC50: 550nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent