BDBM377643 4-{[(6-ethoxy-2-oxo-1,2-dihydroquinolin-3-::US10266495, Compound I-55

SMILES CCOc1ccc2[nH]c(=O)c(CNc3ccc(C#N)c(OC)c3)cc2c1

InChI Key InChIKey=WKFONSVAHXVCCD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 377643   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 377643BDBM377643(US10266495, Compound I-55 | 4-{[(6-ethoxy-2-oxo-1,...)
Affinity DataIC50: 550nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent