BDBM377676 4-[({6-chloro-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-::US10266495, Compound I-88

SMILES COc1cc(NCc2cc3cc(Cl)c(OCCN4CCN(C)CC4)cc3[nH]c2=O)ccc1C#N

InChI Key InChIKey=XRGWIHWIKBCYHZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377676   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 377676BDBM377676(US10266495, Compound I-88 | 4-[({6-chloro-7-[2-(4-...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 377676BDBM377676(US10266495, Compound I-88 | 4-[({6-chloro-7-[2-(4-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent