BDBM377702 US10266496, Example 29

SMILES OC(=O)c1ccc(cc1O)-c1cc(cc2cc(F)oc12)C#N

InChI Key InChIKey=VBWLCOGQAODFLX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 377702   

LigandPNGBDBM377702(US10266496, Example 29)
Affinity DataIC50: 31nMAssay Description:Inhibition of URAT1 (unknown origin) by absorbance based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377702(US10266496, Example 29)
Affinity DataIC50: 34.6nMAssay Description:The compound was diluted 2.5 fold with a buffer of 50 mM KH2PO4 to give a series of concentrations from 2000 nM to 0.524 nM. Then the diluted solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetXanthine dehydrogenase/oxidase(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377702(US10266496, Example 29)
Affinity DataIC50: 35nMAssay Description:Inhibition of xanthine oxidase (unknown origin) by absorbance based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM377702(US10266496, Example 29)
Affinity DataIC50: 38nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent