BDBM378458 N-((1R,3R,5S)-8-(((1s,4S)-4-aminocyclohexyl)sulfonyl)-8-azabicyclo[3.2.1]octan-3-yl)-2-oxoindoline-5-carboxamide::US10266526, Compound 591

SMILES N[C@H]1CC[C@@H](S(=O)(=O)N2[C@@H]3CC[C@H]2C[C@@H](NC(=O)c2ccc4c(c2)CC(=O)N4)C3)CC1

InChI Key InChIKey=GDKZBXGJKICJEC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378458   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandChemical structure of BindingDB Monomer ID 378458BDBM378458(N-((1R,3R,5S)-8-(((1s,4S)-4-aminocyclohexyl)sulfon...)
Affinity DataIC50: 2.33nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent