BDBM378888 Preparation of 3-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo [3, 4-d] pyrimidin-3-yl) ethynyl)-4-methyl-((4-methylpiperazin-1-yl) methyl)-3-(trifluoromethyl) phenyl) benzamide ::US10266537, Compound 120

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nn(C(=O)OC(C)(C)C)c4ncnc(N)c34)cc2C(F)(F)F)CC1

InChI Key InChIKey=VREZKFPACUPTJS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 378888   

TargetTyrosine-protein kinase Yes(Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 11nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src [1-530](Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 12nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 13nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetEphrin type-B receptor 4(Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 28nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
St. Chuan University

US Patent
LigandPNGBDBM378888(US10266537, Compound 120 | Preparation of 3-(4-ami...)
Affinity DataIC50: 91nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent