BDBM379264 US10266549, Example 161a::US10774092, Example 161a

SMILES FC(F)(F)c1cnc(Nc2cnc3[nH]ccc3c2)nc1NC1CCC1

InChI Key InChIKey=CXXJPTXXNKELSZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 379264   

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379264(US10266549, Example 161a | US10774092, Example 161...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379264(US10266549, Example 161a | US10774092, Example 161...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379264(US10266549, Example 161a | US10774092, Example 161...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379264(US10266549, Example 161a | US10774092, Example 161...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed