BDBM379325 US10266549, Example 208a::US10774092, Example 208a

SMILES FC(F)(F)c1cnc(Nc2ccc3ncoc3c2)nc1NC1CC1

InChI Key InChIKey=ZMGUVTBINPLWRA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 379325   

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379325(US10266549, Example 208a | US10774092, Example 208...)
Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed