BDBM379329 N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine::US10266549, Example 211::US10774092, Example 211

SMILES FC(F)(F)c1cnc(Nc2ccc3nc[nH]c3c2)nc1NC1CC1

InChI Key InChIKey=HTSMUTPVZNMYSW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 379329   

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 200nMAssay Description:Gamma-32P assays to measure ULK1 kinase activity were performed as previously described. Briefly, Flag ULK1 was transfected into HEK293T cells and 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 200nMAssay Description:ULK1 inhibition assay is a screening assay to identify compounds that inhibit kinase activity of ULK1 using the ULKtide peptide. In some embodiments,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase ULK1(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 585nMAssay Description:Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 703nMAssay Description:Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Institute

Curated by ChEMBL
LigandPNGBDBM379329(N2-(1H-benzo[d]imidazol-6-yl)-N4-cyclopropyl-5-(tr...)
Affinity DataIC50: 720nMAssay Description:Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed