BDBM380054 2-(3,5-difluorophenyl)- N-[4-(4-oxo-3,4- dihydrophthalazin-1- yl)phenyl]-1,3-thiazole- 4-carboxamide::US9926282, Example 49

SMILES O=C(c1cscn1)N(c1ccc(-c2n[nH]c(=O)c3ccccc23)cc1)c1cc(F)cc(F)c1

InChI Key InChIKey=UISHBPIHHSRFLD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380054   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 380054BDBM380054(2-(3,5-difluorophenyl)- N-[4-(4-oxo-3,4- dihydroph...)
Affinity DataIC50: 100nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 380054BDBM380054(2-(3,5-difluorophenyl)- N-[4-(4-oxo-3,4- dihydroph...)
Affinity DataIC50: 1.00E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent