BDBM380445 5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1H,1′H-4,4′-bipyrazol-1-yl)azetidin-1-yl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrazine-2-carboxamide trifluoroacetate::US10435392, Example 9::US9926301, Example 9

SMILES C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F

InChI Key InChIKey=IGEAGUKQINLFNW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380445   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandPNGBDBM380445(US9926301, Example 9 | 5-[3-(Cyanomethyl)-3-(3R...)
Affinity DataIC50: 300nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandPNGBDBM380445(US9926301, Example 9 | 5-[3-(Cyanomethyl)-3-(3R...)
Affinity DataIC50: 300nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM380445(US9926301, Example 9 | 5-[3-(Cyanomethyl)-3-(3R...)
Affinity DataIC50: 650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM380445(US9926301, Example 9 | 5-[3-(Cyanomethyl)-3-(3R...)
Affinity DataIC50: 650nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent